Author's Response to Reviews Collagen Reorganization at the Tumor-stromal Interface Facilitates Local Invasion Ms# 5901362451064822
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چکیده
We are re-submitting our revised manuscript entitled "Collagen reorganization at the tumor-stromal interface facilitates local invasion" by Paolo P. Provenzano, Kevin W. Eliceiri, Jay M. Campbell, David R. Inman, John G. White, Patricia J. Keely for possible publication as an article in BMC Cancer. We have carefully addressed each of the reviewers' concerns and submit a point-by-point response to each of the reviewers' comments. Additionally, major changes to the text of the manuscript are highlighted with red font.
منابع مشابه
Collagen reorganization at the tumor-stromal interface facilitates local invasion
BACKGROUND Stromal-epithelial interactions are of particular significance in breast tissue as misregulation of these interactions can promote tumorigenesis and invasion. Moreover, collagen-dense breast tissue increases the risk of breast carcinoma, although the relationship between collagen density and tumorigenesis is not well understood. As little is known about epithelial-stromal interaction...
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Cells generate mechanical force to organize the extracellular matrix (ECM) and drive important developmental and reparative processes. Likewise, tumor cells invading into three-dimensional (3D) matrices remodel the ECM microenvironment. Importantly, we previously reported a distinct radial reorganization of the collagen matrix surrounding tumors that facilitates local invasion. Here we describe...
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Stromal changes are the key factors for provision of nutrition and growth to any tumor and also they act as a barrier for spread of the tumor. There are limited histochemical studies in the literature on methods to detect, quantify and analyze the collagen in the invasive tumor front (ITF) of oral squamous cell carcinoma (OSCC). Aim: 1) To analyze the nature of collagen (thickness, hue, density...
متن کاملAuthor's response to reviews Title:Population-based SEER trend analysis of overall and cancer-specific survival in 5,138 patients with gastrointestinal stromal tumor Authors:
Author's response to reviews: Please find the revised manuscript with the requested changes.
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تاریخ انتشار 2006